Mechanistically, nucleic acid loading into EVs occurs via two principal routes: (i) cell engineering based approaches, which exploit endogenous EV biogenesis and RNA-sorting machinery through genetic or transcriptional manipulation of donor cells, and (ii) direct EV engineering, in which isolated vesicles are post-synthetically modified through electroporation, chemical conjugation, or hydrophobic insertion [8]
ARG1 is mainly expressed in the cytoplasm of hepatocytes and plays a role in the urea cycle
In recent years, the exploration of regulated cell death pathways has provided transformative insights into the pathophysiology of chronic diseases
G., Hu, S., & Fernandez, M
doi: 10.1016/j.thromres.2020.04.013 145 KnollR.SchultzeJ
Li Z, Agrawal V, Ramratnam M, Sharma RK, DAuria S, Sincoular A, Jakubiak M, Music ML, Kutschke WJ, Huang XN, Gifford L, Ahmad F (2019) Cardiac sodium-dependent glucose cotransporter 1 is a novel mediator of ischaemia/reperfusion injury